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May 15, Vol. 29, No. 10

  • Feature Articles

    • Natural Resources Buoy Chilean Biotech
    • Robert Yuan, Ph.D.
    • An article in the April 1 issue of GEN described the environment for biotechnology in Chile and the various government programs intended to promote its advancement The main priority has been R&D that will strengthen the country’s major export industries, ... more »
    • New MS Tools Advance Biomolecular Studies
    • K. John Morrow Jr.
    • Mass spectrometry excels as a powerful technique to identify, quantify, and elucidate chemical substances It is notable for its accuracy and sensitivity, and as a result, new applications and advances constantly pour forth Recently launched innovative hardware and software for ... more »
    • "Greening" of Labs and Manufacturing
    • Angelo DePalma
    • The first installment of this article (see GEN, April 1, 2009) discussed the rationale and strategies for greening pharmaceutical and biotech operations, particularly at the corporate and facility level Here we examine laboratory and manufacturing initiatives that fall under the ... more »
    • Nasal Administration Methods Stake Out Niche
    • Alan Smith
    • Recent advances in drug delivery have led to significant innovations including polymer implants, transdermal patches, and sophisticated oral controlled-release formulations These technologies, although in widespread use today, were primarily developed to provide sustained delivery of drugs and thereby reduce dosing ... more »
    • Decoding Cell Communication
    • Kathy Liszewski
    • The intricate interplay of cellular signaling pathways provides a beehive of biologic activity in the nucleus Understanding how these pathways function and dysfunction not only helps trace the roots of cancers and genetic disorders but also suggests new therapeutic targets ... more »
    • Strategies for Removing Viruses from Cell Lines
    • Gail Dutton
    • Cell culture productivity has improved 50-fold during the past 20 years, leading to bottlenecks in downstream processing Increasingly high titers have further slowed processes During the same period, new agents and contamination risks have emerged that have required companies to ... more »