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Exploiting synthetic lethality for cancer therapy.
In our February 1 Point of View article, David Sokal, M.D., says that some innovative nonhormonal approaches that would be highly effective with minimal side effects and, ideally, a more rapid onset of action than hormonal methods may be on the way. S. Kean recently reported in Science on researchers working to halt sperm production; M. O’Rand et al., are working to immobilize sperm; Amobi N et al., are modifying muscle contractility of the vas to prevent passage of sperm; and an Indonesian team may have found a naturally occurring compound that prevents a man’s sperm from penetrating the woman’s egg. Would you or your partner take any of these drugs?
In the near term, what is the best way to use ketamine in treating depression?
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