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GEN’s editor in chief, John Sterling, interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

Scientists at the Huntington Medical Research Institutes have developed a method for reproducibly generating tissue-engineered, 3-D tumor models that contain both tumor cells and stromal elements with a microscopic architecture. The team says the models are so tissue-like that they call them tumor histoids.


 Each histoid is a few tenths of a millimeter in diameter. They are formed by spontaneous interaction of two or more cell types during histoid culture without a support matrix. They also can be produced in quantities large enough for moderately high-throughput drug screening, according to the researchers.


 During this week’s podcast team member Dr. Marylou Ingram discusses in detail the process and tissue-engineering techniques the scientists used to create the novel tumor models. She also describes what makes these particular models so unique. In addition, Dr. Ingram goes over the range of potential applications for their tissue-engineered tumor models.


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