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GEN’s editor in chief, John Sterling, interviews life science academic and biotech industry leaders on important research, technology, and trends. These podcasts will keep you informed with all the important details you need.

A large number of illnesses stem from misfolded proteins. Researchers at the University of Zurich have now studied protein misfolding using a special spectroscopic technique. Misfolding, as they report in a recent issue of Nature, is more frequent if the sequence of the amino acids in the neighboring protein domains is very similar.


During this week’s podcast one of the Nature paper’s authors, Dr. Benjamin Schuler, provides specific examples of diseases that result from problems in protein folding and discusses how he and his team went about investigating the circumstances under which protein misfolding occurs. He describes the type of technology the group used to carry out the research project and reveals the team’s major findings.


Dr. Schuler also talks about the clinical implications of the work on protein misfolding and highlights future laboratory projects designed to take this research to the next level.

Ben Schuler joined the department of Chemistry at the University of Zurich in 2004 and was promoted to full professor of biochemistry in September 2009. He investigates the folding, misfolding, and dynamics of proteins using a close combination of biochemical and spectroscopic methods, in particular single-molecule fluorescence. Dr. Schuler studied biochemistry at the University of Regensburg, Germany, and at the University of Kent, U.K. He received his Ph.D. in physical biochemistry from the University of Regensburg in 1998. He did his postdoctoral research in biophysics at the NIH. Supported by the Emmy Noether Program of the Deutsche Forschungsgemeinschaft, Ben Schuler then headed an independent research group at the University of Potsdam in Germany.


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