GEN Exclusives

More »

GEN News Highlights

More »
Jun 9, 2009

Roche Chooses Fifth Biologic Target to Use with Halozyme Technology

  • Roche has selected a fifth biologic target under the existing license and collaboration agreement with Halozyme Therapeutics. Roche will thus pay $4.25 million for exclusive, global rights to use Halozyme’s recombinant human hyaluronidase, rHuPH20, with this target.

    In December 2006 Roche paid Halozyme $20 million up front to apply the Enhanze™ Technology, a drug delivery platform, to three biological therapeutic compounds. The deal also allowed it to select up to 10 additional targets.

    All told, the deal has a value of over $601 million plus royalties: $20 million up front, $111 million in clinical, regulatory, and sales milestones related to the first three targets, and up to $47 million in initial and milestone fees for each of the additional 10 targets.

    Besides the fee to kick-start the arrangement and today’s payment, Halozyme received $10.25 million in December 2008 with the selection of a fourth target and start of a Phase I study. Roche also initiated a Phase I trial with a biologic directed against its second target in January 2009, but the amount of the milestone payment was not reported.

    The Enhanze Technology is based on rHuPH20, an analogue of a human enzyme that temporarily clears space in the matrix of tissues such as skin. This clearing activity should allow rHuPH20 to improve drug delivery by enhancing the entry of therapeutic molecules through the subcutaneous space.



    ♦♦♦
    Related News from Halozyme

    Halozyme and Baxter Expand Hylenex Deal (Feb. 14, 2007)
    Avid and Halozyme Extend Manufacturing Agreement (Dec. 19, 2006)



Related content

Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Alzheimer's Therapies

Do you think an effective treatment for Alzheimer’s will be found within the next 10–15 years?