GEN Exclusives

More »

GEN News Highlights

More »
Dec 10, 2007

Investigators Identify miRNA Involved in Leukemia

  • Scientists believe that miRNA may play a critical role in the progression of chronic myeloid leukemia (CML) from its more treatable chronic phase to blast crisis by directly controlling a protein’s function.

    The researchers say that for the first time they found that the miRNA molecules sometimes bind directly with proteins and affect their function.

    The investigators found that miR-328 binds with a protein that in blast phase CML prevents immature blood cells from maturing.

    “We believe that miR-328 acts as a decoy molecule that normally ties up the protein, which enables the white blood cells to mature as they should,” says principal investigator, Danilo Perrotti, M.D., Ph.D., assistant professor of molecular virology, immunology, and medical genetics and a researcher with the Ohio State University Comprehensive Cancer Center.

    During progression from chronic-phase to blast-crisis CML, however, the level of miR-328 falls, allowing the protein to be extremely active. This keeps the progenitor white blood cells from maturing, thus favoring blast-crisis conditions.

    The findings were presented at the 2007 annual meeting of the American Society of Hematology.



Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Climate Change and Disease

Are the incursions of dengue fever and West Nile virus into North America just the tip of the iceberg of insect-borne diseases that are migrating due to a warming planet?