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Nov 21, 2012

Fat and Happy: In the Genes?

  • There is new genetic evidence about why some people are happier than others. Researchers at McMaster University uncovered evidence that the gene FTO, the major genetic contributor to obesity, is associated with an 8% reduction in the risk of depression. In other words, it’s not just an obesity gene but a “happy gene” as well. The research appears in a study published yesterday in the journal Molecular Psychiatry.

    “The difference of eight percent is modest and it won’t make a big difference in the day-to-day care of patients,” says David Meyre, Ph.D., associate professor in clinical epidemiology and biostatistics at the Michael G. DeGroote School of Medicine and a Canada research chair in genetic epidemiology. “But, we have discovered a novel molecular basis for depression.”

    Past family studies on twins and siblings have shown a 40% genetic component in depression. But scientific studies attempting to associate genes with depression have been “surprisingly unsuccessful” and produced no convincing evidence so far, says Zena Samaan, Ph.D., assistant professor, department of psychiatry and behavioral neurosciences at McMaster.

    The new discovery challenges the common perception of a reciprocal link between depression and obesity: That obese people become depressed because of their appearance and social and economic discrimination; depressed individuals may lead less active lifestyles and change eating habits to cope with depression that causes them to become obese.

    “We set out to follow a different path, starting from the hypothesis that both depression and obesity deal with brain activity. We hypothesized that obesity genes may be linked to depression,” Dr. Meyre says.

    The team investigated the genetic and psychiatric status of patients enrolled in a study led by the Population Health Research Institute, which analyzed 17,200 DNA samples from participants in 21 countries. In these patients, they found the previously identified obesity predisposing genetic variant in FTO was associated with an 8% reduction in the risk of depression. They confirmed this finding by analyzing the genetic status of patients in three additional large international studies.

    Dr. Meyre says the fact the obesity gene’s same protective trend on depression was found in four different studies supports their conclusion. It is the “first evidence” that an FTO obesity gene is associated with protection against major depression, independent of its effect on body mass index, he notes.


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