GEN Exclusives

More »

GEN News Highlights

More »
Nov 10, 2011

Daiichi Sankyo Licenses Phase I-Ready Cancer Drug Developed Through ArQule Partnership

  • Daiichi Sankyo licensed exclusive worldwide rights to develop and commercialize ARQ 092, the first AKT inhibitor candidate to emerge from an ongoing collaboration with ArQule to develop small molecule kinase inhibitors. The anticancer candidate is expected to start in Phase I development within a few months.

    Signed in 2008, the kinase inhibitor collaboration between Daiichi Sankyo and ArQule is leveraging the ArQule Kinase Inhibitor Platform (AKIP™), a drug discovery engine that targets inactive forms of kinases that play pivotal roles in cancer and other diseases. AKIP integrates in silico drug design with assay development expertise to design non-ATP competitive inhibitors that interact with these kinases in novel binding modes. ArQule says it has already used the platform to identify over 200 human kinases involved in multiple therapeutic areas that are amenable to non-ATP competitive inhibition.

    The Daiichi Sankyo-ArQule collaboration also covers development of the small molecule c-Met receptor tyrosine kinase inhibitor, ARQ 197 (tivantinib), which is currently undergoing Phase III evaluation as a treatment for non-squamous, non-small cell lung cancer. Under terms of this deal Daiichi Sankyo has rights to the compound worldwide, except Japan and certain other Asian countries, where commercial rights have been licensed to Kyowa Hakko Kirin.

    ArQule’s in-house pipeline includes two Phase I-stage compounds. ARQ 736 is a pan-RAF kinase inhibitor, and ARQ 621 is an inhibitor of the Eg5 kinesin motor protein. 


Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content

Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Alzheimer's Therapies

Do you think an effective treatment for Alzheimer’s will be found within the next 10–15 years?