Research reagents supply company Axxora negotiated North American distribution rights to Sweden-based Olink Bioscience’s Duolink® reagent product line. The Duolink products are based on Olink’s in situ PLA™ (proximity ligation assay) technology, which the company claims enables researchers to detect and individually count single endogenous proteins, protein-protein interactions, and protein phosphorylations in fixed cells and tissue samples.
The PLA technology hinges on two unique bi-functional PLA probes, each of which consists of an antibody attached to a unique synthetic oligonucleotide reporter. The approach requires positive identification of two different epitopes on the same protein or complex. This results in what Olink claims to be profoundly enhanced specificity compared with assays that depend on single-binding recognition.