Because of a C-terminus sequence composed primarily of hydrophobic amino acids, beta-amyloid peptides with sequences 1-44 to 1-48 have not been commercially available. AnaSpec now offers beta-amyloid peptides for sequences 1-44, 1-45, 1-46, 1-47, 1-48, and 1-49.
"With the successful commercialization of these longer beta-amyloid peptides, we are pleased to offer an even broader selection of amyloid-related products for our customers," states AnaSpec president, Anita Hong.
Amyloid Precursor Protein is predominantly processed by alpha-secretase, while a small amount is processed by beta-secretase, which produces a 99-amino acid C-terminal fragment, C99. Subsequent cleavages of C99 by gamma-secretase produce a 4-kD (beta-amyloid) protein. The 4-Kd consists of beta-amyloids that are 39–42 amino acids in length, with beta-amyloid 1-42 being the major component of amyloid plaques that accumulate in neurons of Alzheimer's diseased brains. Novel cleavage sites (epsilon and zeta) downstream of the gamma-cleavage site have recently been reported, which release longer beta-amyloid peptides (1-43, 1-45, 1-46 and 1-48).