Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN Exclusives

More »

For full access to this article login to GEN Select now.

June 02, 2014

Targeting the Tumor Microenvironment

Humanizing mouse models of cancer to expand drug development opportunities.

Targeting the Tumor Microenvironment

Patient-derived xenograft tumor (PDX) models can provide a more relevant heterogeneous system in which human tumor and stromal cells are in close cooperation within a unique microenvironment. [© vitanovski - Fotolia.com]

Introduction
The majority of cancer drugs entering Phase I clinical studies fail to reach the market The success rate in predicting clinical efficacy of anticancer modalities using standard xenograft models has been reported to be only 30-40%, 1-2 which is leading to the re-evaluation of both in vivo and in vitro ...

Not registered yet? Please fill out the form below and enjoy complimentary access to this and an exclusive collection of premium content and personalization features as a GEN Select insider. Learn More.

Get GEN Select Access Now

    • Do not put any letters or characters here if you are not a spy program.

Related content