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March 28, 2014

Repurposing the PacBio Sequencer

A review of literature where the authors customize a DNA sequencer to use as an instrument for single-molecule fluorescence detection.

Repurposing the PacBio Sequencer

The PacBio RS II operates on the principle of zero-mode waveguide (ZMW) detection.

The team from Pacific Biosciences* presents a modified version of their RS II sequencer, which allows the execution of single-molecule fluorescence detection experiments to monitor complex conformational dynamics and reaction events (see Figure 1 )...

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