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March 20, 2014

A New Way to Interrogate PTPs

A review of literature describing an assay that could help researchers use protein tyrosine phosphatases in drug development.

A New Way to Interrogate PTPs

Protein tyrosine phosphatases, or PTPs, feature in signal transduction pathways. [© lculig - Fotolia.com]

Protein tyrosine phosphatases (PTPs) control posttranslational tyrosine phosphorylation, and thus play a critical role in the regulation of many signaling molecules Despite the disease relevance of PTPs (for example, PTP1B is considered a target for treatment of diabetes type 2; DEP1 and PTPγ are cancer targets) and several PTP inhibitors ...

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