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May 01, 2014 (Vol. 34, No. 9)

When Signaling Pathways Turn Awry

  • In a complex system of communication, cells interact with their environment and other cells via signaling pathways. Signaling pathways involve a variety of biochemical messengers that bind to protein receptors, initiating cellular responses. When these pathways turn awry, whether by gene mutation or dysregulation, the all-too-frequent result is tumorigenesis. ...

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