Earlier this year, Dasgip, a developer, manufacturer, and supplier of parallel bioreactor systems and accompanying bioprocess control software, was acquired by Eppendorf, a combination that Thomas Drescher, Ph.D., Dasgip’s CEO, calls “an excellent fit.”
As a result of the acquisition, Eppendorf gained Dasgip’s expertise in the area of parallel bioprocessing, complementing the bioreactor product line it gained with the earlier acquisition of New Brunswick Scientific. Dasgip benefits from access to Eppendorf’s range of products and expertise in the areas of liquid, sample, and cell handling and to its global sales and service capabilities.
Eppendorf now offers products for bioprocess research applications, development, and scale-up ranging from 30 mL to 3,000 liters.
Falk Schneider, Ph.D., head of software development at Dasgip, describes a key trend driving the bioreactor market over the past 6–12 months. “We are recognizing an increasing demand for cultivation in a scale below 1 L in the market,” he says. “This demand is driven by applications in the fields of strain and cell line screening, media optimization, and process development.”
Furthermore, he notes, “QbD methods have gained a broad awareness over the last year and are considered to be a tool to minimize the necessary amount of cultivation runs and at the same time gain the most valuable information out of them.”
Dasgip recently introduced the DASbox mini bioreactor system. It is a controlled stirred tank bioreactor with a working volume of 60–250 mL. Drawing on Dasgip’s hardware and software design innovations for parallel bioprocessing, the DASbox comes in units of four, allowing for 32+ fold parallel systems to operate simultaneously.
A 24-fold system consumes only six feet of lab bench space, according to Matthias Arnold, Ph.D., head of hardware development.
“The burden of liquid cooling and heating has been completely eliminated by using peltier elements to control the temperature of bioreactors as well as condensors.”
An overhead drive covers the full range from 30 rpm to 3,000 rpm and can serve cell culture as well as microbial applications at the same time. The DASbox also incorporates mass flow controlled gassing.