The SBS meeting marked the U.S. launch of Reinnervate’s alvetex® cell culture scaffold for 3-D in vitro cell growth. Initially marketed in Europe in a 12-well plate format, alvetex is now available as 6-well and 12-well inserts. It is supplied as a gamma-irradiated, ready-to-use polystyrene membrane and can be optimized for specific cell types and applications. Users can control the degree of penetration within the 3-D structure and optimize the culture format and parameters to support long-term cell culture. The new well inserts allow cells to be fed simultaneously from above and below. They fit into multiwell plates or into insert holders designed to fit into a Petri dish.
Jens Kelm, head of product management and co-founder of InSphero, presented a tutorial on the benefits of using 3-D microtissue models for screening to evaluate drug efficacy and toxicity. InSphero developed an assay-ready microtissue mass production technology that generates 3-D microtissues of various tissue types containing 100–5,000 cells, without the use of a scaffold. Customers can purchase standard microtissues or provide InSphero with their own cell lines. The company recently introduced tumor microtissue models for colon, liver, prostate, and kidney cancer.
The Automation Partnership recently announced a name change to TAP Biosystems. The company also introduced a 96-well version of its RAFT™ (Real Architecture for 3D Tissue™) system for generating multi-cellular 3-D collagen-based tissue models.
Kuraray’s micro-space cell culture plate designed to support 3-D cell growth is currently available in Japan and will be introduced to the European and U.S. markets in early to mid-2012.