Harvesting Stem Cells with Sound
“At the end of the day with our technology, we make more cells, cheaper cells, and faster cells,” said Steven Victor, M.D, CEO of Intellicell Biosciences, when comparing Intellicell technology to other adipose stromal vascular fraction (SVF) harvesting methods.
Intellicell uses ultrasonic cavitation, a phenomenon that occurs with the formation and collapse of microscopic bubbles as a result of an ultrasound pressure gradient. Ultrasonic cavitation strictly utilizes mechanical forces to separate the SVF from white adipose tissue. It does not require the addition of exogenous digestive enzymes, or other purification steps that are common with other SVF harvesting methods.
Additionally, since ultrasonic cavitation lyses red blood cells, the blood does not need to be removed and the “hematopoietic stem cells, plasma, platelets, and other important health factors of the blood” are retained in the SVF population, Dr. Victor said.
Compared to other methods, ultrasonic cavitation provides over twice as many SVF cells from less than half the extracted adipose tissue, with minimal laboratory manipulation. For these reasons, this product falls under FDA 361 guidelines, which will allow the extracted SVF cells to be used off-label and at the discretion of licensed physicians.
Composed of mesenchymal stem cells and other important cell populations, including pre-adipocytes, endothelial cells, smooth muscle cells, fibroblasts, important immune cells, as well as variety of growth factors, the SVF, according to Dr. Victor, is more therapeutically efficacious than stem cells alone. It is pluripotent, exhibits homing characteristics, and can provide clinical regenerative healing in a variety of tissue. Furthermore, since the SVF is extracted from the patient, it is also autologous with minimal risk of an immune response.
Presently Intellicell is largely researching the clinical application of this technology in “three therapeutic worlds”: cosmetics, peridontal medicine, and orthopedics. It is in the process of organizing several clinical trials, including a multicenter study in collaboration with a sports orthopedic medical doctor on the use of ultrasonic cavitation-purified adipose SVF on osteoarthritis of the knee.
To extend its clinical application beyond the focus of Intellicell, the ultrasonic cavitation technology is also licensed worldwide to industry and research leaders to test its clinical effectiveness against other indications including wound healing, cardiac disease, multiple sclerosis, and autism.