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High Throughput Screening of GPCRs
New Tricks and Novel Techniques
- More than 50% of all current drugs and nearly 25% of the top 200 best-selling drugs target G-protein-coupled receptors (GPCRs).These heterotrimeric proteins contain seven membrane-spanning segments and consist of α, β, and γ subunits. To add to the complexity, there are four main subfamilies depending upon their a-subunit ...
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