Revolutionizing Virus Filtration with Planova
Planova 15N, 20N, 35N, and 75N virus-removal filters operate by size exclusion and are available in four nominal pore sizes: 15 nm, 19 nm, 35 nm, and 72 nm, respectively. Viruses become trapped in the interconnected network of void and capillary pores present in hollow-fiber membrane walls. This robust virus-removal mechanism allows virus to be retained while maximizing protein yield, as product is not adsorbed.
Process scale-up is simplified because Planova filters are available in surface area sizes from 0.001 m2 to 4.0 m2 with the same standardized hollow-fiber format. Following Planova filtration, mandatory post-use integrity testing is expedited using the automated Asahi Gold Particle Test System (AGPTS).
For filtrations involving high protein concentrations and higher pressures, Planova BioEX is ideal. Made of polyvinylidene fluoride (PVDF), Planova BioEX combines the reliable performance and scalability of Planova filters with a simplified and sensitive integrity test. All Planova filters are compatible with the new Virus Filtration Controller (VFC). Since floor space in manufacturing facilities is limited, the VFC provides consistent, automated virus removal in a compact footprint.