Individual Tumor Profiling
Has Tumor Molecular Profiling Enabled More Effective and Less Toxic Cancer Treatment?
Top 10 Under 40
Up-and-Coming Stars Shine in Biopharma Research and Business
Podcast: FDA’s New Commissioner Hits the Ground Running
Scott Gottlieb, M.D., Commits to Speeding Up Drug Reviews, and Maintaining Safety and Efficacy
Liquid Biopsies Remain Wait and See for Some Clinicians
Circulating Biomarker Assays Promise to Refresh Cancer Profiling and Monitoring Practices
SPdb: A Signal Peptide Database
The GPS of the protein world, signal peptides direct proteins to their correct destinations within the cell. (Take a left at the mitochondrion, then proceed for five microns.) With SPdb, researchers from the National University of Singapore and Macquarie University in Australia provide a way for scientists to navigate the myriad signal peptides found in archaea, prokaryotes, eukaryotes, and viruses. Integrating information derived from two databases, the EMBL nucleotide sequence database and the Swiss-Prot protein sequence database, SPdb currently contains a whopping 27,433 entries. Among those entries, you can search by organism or broad data group (such as eukaryotes), and you can choose to filter the results to include only those entries that have been experimentally verified. (Sadly, though, this limits you to only 9.2% of the sequences in the database.) So go ahead and maneuver yourself over to this great database—no GPS or driving directions required!