As you know, the liver does much more than cope with the alcoholic aftermath of the Friday afternoon happy hour at your lab. The members of the cytochrome P450 superfamily of enzymes, the “worker bees” of the liver, are hard at work oxidizing xenobiotic substances and metabolic intermediates. A great resource to explore the vastness of this superfamily is provided by David Nelson of the University of Tennessee Health Science Center. His “Cytochrome P450 Homepage” provides pages upon pages of P450 information for a number of species, along with phylogenetic trees, 3-D structures, nomenclature resources, and plenty of additional links. Although the website isn’t the most polished in appearance, Dr. Nelson has certainly compiled enough resources to make this a true “home base” for researchers in search of P450 information.